U2SURP

Across TCGA cell cohorts, U2SURP mutation is significantly associated with the RNA expression of many other genes, with 260 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible U2SURP-associated genes across cancer lineages are UTF1, LGALS16, and OR1N2. Each is linked with U2SURP in more than 1 cancer types. Because this analysis shows association rather than direction, both U2SURP-to-partner and partner-to-U2SURP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTF1 grouped by U2SURP-low versus U2SURP-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (U2SURP→partner) and Y-score (partner→U2SURP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	UTF1 →	+0.046	+4.906	<.001	.006	3	1
OESOPHAGUS	LGALS16 →	+0.046	+4.906	<.001	.006	3	1
BREAST	OR1N2 →	+0.038	+4.199	<.001	.007	3	1
BREAST	CACNG5 →	+0.205	+4.421	<.001	.004	3	1
LARGE_INTESTINE	GCAT →	+1.148	+2.628	.001	.002	3	1
LARGE_INTESTINE	DEPDC5 →	+0.501	+3.169	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 260 associations by consensus.

UTF1 by U2SURP expression — OESOPHAGUS

Explore this box plot interactively →