TYW5

Across TCGA patient cohorts, TYW5 mutation is significantly associated with the RNA expression of many other genes, with 2,069 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYW5-associated genes across cancer lineages are RNU6-1234P, GOLGA2P11, and MIR4710. Each is linked with TYW5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TYW5-to-partner and partner-to-TYW5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1234P grouped by TYW5-low versus TYW5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYW5→partner) and Y-score (partner→TYW5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1234P →	+0.334	+5.547	.007	.002	3	2
COAD	GOLGA2P11 →	+0.447	+4.717	<.001	.003	3	2
COAD	MIR4710 →	+0.700	+4.602	<.001	.008	3	2
UCEC	TRAJ21 →	+0.328	+1.828	.002	.003	3	2
UCEC	RNA5SP369 →	+0.240	+1.670	.003	.006	3	2
STAD	RNU6-499P →	+0.332	+3.682	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,069 associations by consensus.

RNU6-1234P by TYW5 expression — COAD

Explore this box plot interactively →