TYW5

Across TCGA pan-cancer cohorts, TYW5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TYW5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TYW5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TYW5 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BLCA, and LUAD are the cancer types where TYW5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TYW5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.717	<.001	11	view →
BLCA	Female	III,IV	+0.528	<.001	11	view →
LUAD	All	All	+0.397	<.001	9	view →
STAD	All	II,III,IV	+0.587	<.001	8	view →
LIHC	All	All	+0.320	<.001	7	view →
COAD	Male	II,III,IV	+0.419	<.001	6	view →
CHOL	All	All	+1.229	<.001	5	view →
READ	All	III,IV	+0.510	.003	5	view →
LUSC	Male	All	+0.420	<.001	5	view →
UCEC	All	II,III,IV	+0.485	.009	4	view →
KICH	All	All	−0.469	<.001	4	view →
BRCA	All	II,III,IV	+0.166	.026	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TYW5–HNSC

Open the HNSC breakdown →