TYSND1

Across TCGA cell cohorts, TYSND1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TYSND1-associated genes across cancer lineages are CPLX4, CLRN1, and TMEM132C. Each is linked with TYSND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TYSND1-to-partner and partner-to-TYSND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPLX4 grouped by TYSND1-low versus TYSND1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYSND1→partner) and Y-score (partner→TYSND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CPLX4 →	+0.035	+3.807	<.001	.001	3	1
BLOOD_Leukemia	CLRN1 →	+0.113	+3.551	<.001	.009	3	1
BLOOD_Leukemia	TMEM132C →	+0.983	+4.966	<.001	<.001	3	1
BLOOD_Leukemia	TBPL2 →	+0.132	+4.044	<.001	.004	3	1
BLOOD_Leukemia	FIGLA →	+0.022	+4.984	<.001	.002	3	1
BLOOD_Leukemia	TBC1D3H →	+0.695	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CPLX4 by TYSND1 expression — LARGE_INTESTINE

Explore this box plot interactively →