TYROBP

Across TCGA patient cohorts, TYROBP mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYROBP-associated genes across cancer lineages are LINC02240, RNU6-142P, and TMEM97P1. Each is linked with TYROBP in more than 1 cancer types. Because this analysis shows association rather than direction, both TYROBP-to-partner and partner-to-TYROBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02240 grouped by TYROBP-low versus TYROBP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYROBP→partner) and Y-score (partner→TYROBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02240 →	+0.396	+4.089	.001	.002	3	2
SKCM	RNU6-142P →	+0.239	+3.923	<.001	.003	3	2
SKCM	TMEM97P1 →	+0.236	+3.851	<.001	.004	3	1
SKCM	OR4A47 →	+0.105	+3.669	<.001	.006	3	1
SKCM	LINC01808 →	+0.032	+5.219	<.001	.002	3	1
SKCM	HMGN1P11 →	+0.283	+3.287	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

LINC02240 by TYROBP expression — SKCM

Explore this box plot interactively →