TYROBP

Across TCGA pan-cancer cohorts, TYROBP RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TYROBP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TYROBP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TYROBP is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where TYROBP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TYROBP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+3.080	<.001	12	view →
KIRP	Male	All	+2.407	<.001	11	view →
THCA	Male	II,III,IV	+1.721	<.001	10	view →
LUAD	Male	II,III,IV	−1.915	<.001	9	view →
LUSC	Male	II,III,IV	−2.376	<.001	8	view →
HNSC	Female	All	+1.183	.001	8	view →
STAD	All	II,III,IV	+1.338	.001	7	view →
ESCA	All	All	+1.977	.016	4	view →
BRCA	Female	All	+0.416	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TYROBP–KIRC

Open the KIRC breakdown →