TYROBP

Across TCGA pan-cancer cohorts, TYROBP RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TYROBP data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TYROBP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TYROBP expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

UVM, SKCM, and CESC are the cancer types where TYROBP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.389	0.819	<.001	69	view →
SKCM	OS	Median	All	0.406	0.276	<.001	67	view →
CESC	DFS	Quartile	II,III,IV	0.975	0.698	<.001	56	view →
LGG	OS	Tertile	All	0.367	0.597	<.001	45	view →
HNSC	DFS	Quartile	III,IV	0.708	0.470	<.001	34	view →
ACC	OS	Median	III,IV	0.234	0.714	.002	29	view →
KIRC	DFS	Median	IV	0.216	0.445	.002	26	view →
CHOL	DFS	Tertile	All	0.615	0.179	.007	22	view →
GBM	DFS	Quartile	All	0.198	0.557	<.001	15	view →
THYM	OS	Median	All	0.699	1.000	.015	12	view →
LUSC	OS	Quartile	II,III,IV	0.533	0.705	.019	10	view →
MESO	DFS	Median	II,III,IV	0.309	0.591	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TYROBP–UVM (OS)

Open the UVM breakdown →