TYROBP

Across TCGA cell cohorts, TYROBP RNA expression is significantly associated with the go_rna of many other GO terms, with 2,758 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TYROBP-associated GO terms across cancer lineages are Regulation of macrophage fusion, Positive regulation of macrophage fusion, and Positive regulation of mitochondrial membrane permeability. Each is linked with TYROBP in more than 6 cancer types. Because this analysis shows association rather than direction, both TYROBP-to-partner and partner-to-TYROBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macrophage fusion grouped by TYROBP-low versus TYROBP-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TYROBP→partner) and Y-score (partner→TYROBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of macrophage fusion →	-0.261	-0.466	.001	.003	1	7
LUNG_SCLC	Positive regulation of macrophage fusion →	-0.261	-0.466	.001	.003	1	7
BLOOD_Leukemia	Positive regulation of mitochondrial membrane permeability →	-0.089	-2.795	<.001	<.001	3	4
KIDNEY	Postsynaptic density assembly →	+0.167	+0.057	<.001	.004	3	4
BLOOD_Leukemia	Regulation of sensory perception of pain →	-0.163	-3.275	<.001	<.001	3	4
BLOOD_Leukemia	Regulation of sensory perception →	-0.163	-3.275	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,758 associations by consensus.

Regulation of macrophage fusion by TYROBP expression — LUNG_SCLC

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