TYRO3

Across TCGA patient cohorts, TYRO3 mutation is significantly associated with the RNA expression of many other genes, with 1,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYRO3-associated genes across cancer lineages are RNU6-552P, RNU6-693P, and EXOC7P1. Each is linked with TYRO3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TYRO3-to-partner and partner-to-TYRO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-552P grouped by TYRO3-low versus TYRO3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYRO3→partner) and Y-score (partner→TYRO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-552P →	+0.297	+3.691	<.001	.004	3	4
LGG	RNU6-693P →	+0.303	+7.977	<.001	.007	3	3
LIHC	EXOC7P1 →	+0.025	+6.902	<.001	<.001	3	2
CESC	RN7SL447P →	+0.237	+5.201	<.001	.007	3	2
CESC	RNU6-362P →	+0.921	+7.584	<.001	<.001	3	2
CESC	RN7SL237P →	+0.271	+5.418	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,015 associations by consensus.

RNU6-552P by TYRO3 expression — BLCA

Explore this box plot interactively →