TYRO3

Across TCGA patient cohorts, TYRO3 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYRO3-associated genes across cancer lineages are Caspase-7-cleavedD198, GSK-3_pS9, and GSK-3a-b_pS21_S9. Each is linked with TYRO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TYRO3-to-partner and partner-to-TYRO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TYRO3-low versus TYRO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYRO3→partner) and Y-score (partner→TYRO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.877	+2.938	<.001	<.001	3	3
STAD	GSK-3_pS9 →	-0.546	-3.000	.004	.036	3	2
STAD	GSK-3a-b_pS21_S9 →	-0.544	-3.000	.002	.036	3	2
STAD	ACVRL1 →	-0.254	-2.978	.023	.036	3	2
UCEC	HSP70 →	-0.314	-2.105	.024	.017	3	2
UCEC	JNK2 →	+0.157	+1.736	.023	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Caspase-7-cleavedD198 by TYRO3 expression — UCEC

Explore this box plot interactively →