TYRO3

Across TCGA cell cohorts, TYRO3 mutation is significantly associated with the RNA expression of many other genes, with 549 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TYRO3-associated genes across cancer lineages are OR1L3, ZSCAN1, and FOXR2. Each is linked with TYRO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TYRO3-to-partner and partner-to-TYRO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by TYRO3-low versus TYRO3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYRO3→partner) and Y-score (partner→TYRO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR1L3 →	+0.042	+4.029	<.001	.009	3	2
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	FOXR2 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
BLOOD_Lymphoma	FAM71C →	+0.029	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	SPRR2B →	+0.025	+4.643	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 549 associations by consensus.

OR1L3 by TYRO3 expression — OVARY

Explore this box plot interactively →