TYRL

Across TCGA patient cohorts, TYRL protein abundance is significantly associated with the RNA expression of many other genes, with 123 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TYRL-associated genes across cancer lineages are USP14, SQLE, and PSMD3. Each is linked with TYRL in more than 1 cancer types. Because this analysis shows association rather than direction, both TYRL-to-partner and partner-to-TYRL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TYRL versus USP14 in BRCA, with a Pearson correlation of 0.75.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYRL→partner) and Y-score (partner→TYRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	USP14 →	+0.898	+0.378	<.001	.004	3	1
BRCA	SQLE →	+0.864	+0.396	.006	.004	3	1
BRCA	PSMD3 →	+0.469	+0.446	<.001	.001	3	1
BRCA	PPY →	+0.117	+0.341	<.001	.005	3	1
BRCA	CNR1 →	-1.166	-0.328	.009	.005	3	1
BRCA	DUSP4 →	-2.322	-0.321	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 123 associations by consensus.

TYRL vs USP14 — BRCA

Explore this scatter interactively →