Q-omics provides the consensus-scored TYRL profile across patient tissues and cancer cell-line models. TYRL expression is associated with patient survival in 8 of 34 cancer types, with the highest sampling consensus in BLCA. Additionally, TYRL RNA expression shows 6,514 significant gene co-expression associations, with the highest sampling consensus in SKCM. Together, these results highlight BLCA, and SKCM as cancer lineages where TYRL shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes TYRL survival associations across molecular data types. TYRL RNA expression shows survival associations in the most cancer types (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

TYRL data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	8	BLCA (108)	view →

This table ranks reproducible TYRL RNA expression–survival associations across cancer types. High TYRL expression shows unfavorable associations in BLCA, KICH, SKCM, HNSC, KIRC and STAD. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for TYRL RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.111	0.720	<.001	108	view →
KICH	OS	Tertile	All	0.410	0.893	<.001	105	view →
SKCM	OS	Tertile	IV	0.201	0.696	<.001	36	view →
HNSC	DFS	Tertile	II,III,IV	0.140	0.667	<.001	36	view →
KIRC	DFS	Tertile	IV	0.127	0.619	.008	36	view →
STAD	DFS	Tertile	All	0.415	0.719	.030	18	view →

Pink = unfavorable, green = favorable. all 8 lineages →

TYRL-BLCA (OS)

Kaplan–Meier survival curve for TYRL RNA expression in BLCA: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with TYRL in patient tissues and cancer cell lines. In patient samples, TYRL shows the broadest associations at the RNA and protein expression levels, with SKCM recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	6,514	SKCM (1856)	view →
Function (RNA)	5,851	STAD (4624)	view →
▼Protein (mass-spec)
Protein (mass-spec)	188	BRCA (188)	view →
RNA	123	BRCA (123)	view →