TYK2

Across TCGA cell cohorts, TYK2 mutation is significantly associated with the RNA expression of many other genes, with 735 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TYK2-associated genes across cancer lineages are FRA10AC1, GDF9, and ALG6. Each is linked with TYK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TYK2-to-partner and partner-to-TYK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRA10AC1 grouped by TYK2-low versus TYK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYK2→partner) and Y-score (partner→TYK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FRA10AC1 →	+0.569	+3.489	.001	.001	3	3
BLOOD_Leukemia	GDF9 →	+0.520	+3.115	<.001	.009	3	3
LARGE_INTESTINE	ALG6 →	+0.494	+2.451	.004	.009	3	3
BREAST	GPR148 →	+0.046	+4.087	<.001	<.001	3	2
BREAST	SFT2D3 →	+0.681	+3.232	<.001	.006	3	2
BREAST	OR10T2 →	+0.091	+3.781	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 735 associations by consensus.

FRA10AC1 by TYK2 expression — BLOOD_Leukemia

Explore this box plot interactively →