TYK2

Across TCGA pan-cancer cohorts, TYK2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TYK2 data layer compared with 12 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TYK2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TYK2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, ACC, and KICH are the cancer types where TYK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.779	0.637	<.001	141	view →
ACC	DFS	Median	All	0.339	0.815	<.001	94	view →
KICH	DFS	Tertile	III,IV	0.059	1.000	.002	85	view →
PAAD	DFS	Median	All	0.448	0.274	<.001	69	view →
UCEC	DFS	Median	III,IV	0.873	0.714	.001	66	view →
KIRC	DFS	Tertile	II,III,IV	0.384	0.650	<.001	57	view →
LGG	DFS	Median	All	0.637	0.836	<.001	50	view →
CESC	OS	Quartile	II,III,IV	0.948	0.732	.012	26	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	18	view →
PRAD	DFS	Quartile	All	0.713	0.902	.009	18	view →
ESCA	OS	Tertile	All	0.613	0.419	.030	16	view →
LUAD	OS	Median	III,IV	0.781	0.540	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TYK2–HNSC (DFS)

Open the HNSC breakdown →