TXNL4B

Across TCGA patient cohorts, TXNL4B mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TXNL4B-associated genes across cancer lineages are MIR520H, RNU6-775P, and RNU6-717P. Each is linked with TXNL4B in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNL4B-to-partner and partner-to-TXNL4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR520H grouped by TXNL4B-low versus TXNL4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNL4B→partner) and Y-score (partner→TXNL4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR520H →	+0.519	+4.997	<.001	.003	3	2
SKCM	RNU6-775P →	+0.358	+7.816	<.001	.008	3	1
SKCM	RNU6-717P →	+0.338	+7.816	<.001	.008	3	1
BLCA	RNA5SP66 →	+0.278	+7.640	<.001	.009	3	1
UCEC	POTED →	+0.023	+4.267	<.001	.009	3	1
UCEC	OR4B1 →	+0.099	+5.356	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

MIR520H by TXNL4B expression — UCEC

Explore this box plot interactively →