TXNL4B

Across TCGA pan-cancer cohorts, TXNL4B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TXNL4B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TXNL4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TXNL4B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where TXNL4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TXNL4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.850	<.001	11	view →
KIRC	Male	All	+0.421	<.001	11	view →
BLCA	All	III,IV	+0.805	<.001	10	view →
LIHC	Male	II,III,IV	+0.835	<.001	9	view →
KIRP	All	IV	+1.272	<.001	8	view →
COAD	Female	II,III,IV	+0.637	<.001	8	view →
THCA	Female	All	−0.318	<.001	7	view →
KICH	Female	All	−0.757	<.001	6	view →
LUSC	Male	All	+0.530	<.001	5	view →
LUAD	All	All	+0.234	<.001	5	view →
CHOL	Male	All	+1.369	<.001	4	view →
STAD	All	All	+0.566	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TXNL4B–HNSC

Open the HNSC breakdown →