TXNL4B

Across TCGA pan-cancer cohorts, TXNL4B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TXNL4B data layer compared with 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TXNL4B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TXNL4B expression acts as an unfavorable survival marker, although some lineages such as MESO and THYM show a favorable association.

ACC, MESO, and LGG are the cancer types where TXNL4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.256	0.657	<.001	80	view →
MESO	OS	Tertile	III,IV	0.809	0.267	.006	63	view →
LGG	OS	Median	All	0.346	0.532	<.001	53	view →
LIHC	DFS	Quartile	All	0.410	0.594	.001	36	view →
KIRC	DFS	Tertile	II,III,IV	0.556	0.772	.002	29	view →
THYM	DFS	Tertile	All	0.900	0.615	.001	28	view →
OV	OS	Median	III,IV	0.893	0.776	.002	24	view →
ESCA	OS	Median	All	0.590	0.756	.014	24	view →
UVM	DFS	Median	All	0.851	0.596	.021	21	view →
THCA	DFS	Quartile	II,III,IV	0.553	0.841	.022	20	view →
STAD	OS	Median	II,III,IV	0.450	0.689	.028	20	view →
LUAD	DFS	Median	IV	0.777	0.212	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TXNL4B–ACC (DFS)

Open the ACC breakdown →