TXNDC12

Across TCGA patient cohorts, TXNDC12 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNDC12-associated genes across cancer lineages are FoxM1, mTOR, and Paxillin. Each is linked with TXNDC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC12-to-partner and partner-to-TXNDC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TXNDC12-low versus TXNDC12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC12→partner) and Y-score (partner→TXNDC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.300	+3.009	.021	.019	3	1
UCEC	mTOR →	-0.270	-2.321	<.001	.035	3	1
UCEC	Paxillin →	+0.298	+3.009	.021	.019	3	1
UCEC	PDCD4 →	-0.566	-3.459	.016	.005	3	1
UCEC	Tuberin →	+0.432	+2.321	.001	.035	3	1
UCEC	XBP1 →	-0.226	-3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FoxM1 by TXNDC12 expression — UCEC

Explore this box plot interactively →