TXNDC12

Across TCGA pan-cancer cohorts, TXNDC12 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TXNDC12 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TXNDC12 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TXNDC12 expression acts as an unfavorable survival marker, although some lineages such as COAD and PRAD show a favorable association.

KIRP, HNSC, and LIHC are the cancer types where TXNDC12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.748	0.943	<.001	131	view →
HNSC	DFS	Median	All	0.639	0.748	<.001	127	view →
LIHC	DFS	Median	All	0.435	0.647	<.001	88	view →
ACC	DFS	Tertile	All	0.197	0.771	<.001	76	view →
MESO	OS	Median	All	0.403	0.677	<.001	58	view →
LGG	DFS	Median	All	0.638	0.846	<.001	54	view →
PAAD	OS	Tertile	All	0.260	0.541	.001	48	view →
COAD	OS	Median	III,IV	0.636	0.423	.003	44	view →
LAML	DFS	Quartile	All	0.226	0.570	.005	36	view →
UCS	DFS	Tertile	IV	0.401	0.981	.024	24	view →
KICH	OS	Quartile	II,III,IV	0.336	1.000	.004	21	view →
SKCM	DFS	Median	III,IV	0.510	0.770	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TXNDC12–KIRP (DFS)

Open the KIRP breakdown →