TXNDC12

Across TCGA pan-cancer cohorts, TXNDC12 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of TXNDC12’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TXNDC12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TXNDC12 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where TXNDC12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TXNDC12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.418	<.001	12	view →
KIRC	All	IV	+0.714	<.001	12	view →
BLCA	All	III,IV	+1.128	<.001	11	view →
KIRP	All	II,III,IV	+0.843	<.001	11	view →
KICH	Female	II,III,IV	−1.985	<.001	9	view →
LIHC	Female	II,III,IV	+0.910	<.001	9	view →
STAD	All	All	+1.111	<.001	8	view →
COAD	Male	II,III,IV	+0.624	<.001	8	view →
THCA	Male	III,IV	−0.598	<.001	8	view →
LUAD	Male	All	+0.445	<.001	7	view →
LUSC	Female	All	+0.867	<.001	6	view →
UCEC	All	III,IV	+0.845	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

TXNDC12–HNSC

Open the HNSC breakdown →