TXN

Across TCGA cell cohorts, TXN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,213 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TXN-associated GO terms across cancer lineages are Proteasome regulatory particle assembly, Positive regulation of DNA recombination, and Proteasome assembly. Each is linked with TXN in more than 13 cancer types. Because this analysis shows association rather than direction, both TXN-to-partner and partner-to-TXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proteasome regulatory particle assembly grouped by TXN-low versus TXN-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TXN→partner) and Y-score (partner→TXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Proteasome regulatory particle assembly →	+0.134	+1.124	<.001	<.001	3	14
BONE	Positive regulation of DNA recombination →	-0.103	-0.813	<.001	<.001	3	10
LIVER	Proteasome assembly →	+0.096	+1.397	.001	<.001	3	9
LUNG_NSCLC_LUSC	Secondary metabolic process →	+0.344	+1.244	<.001	.001	3	9
OESOPHAGUS	Ketone metabolic process →	+0.126	+1.297	.004	.007	2	9
KIDNEY	Long-chain fatty acid metabolic process →	+0.082	+0.837	.005	.009	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,213 associations by consensus.

Proteasome regulatory particle assembly by TXN expression — UPPER_AERODIGESTIVE_TRACT

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