TXN

Across TCGA pan-cancer cohorts, TXN RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TXN’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where TXN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TXN is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

LIHC, KIRC, and LUSC are the cancer types where TXN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TXN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+1.709	<.001	9	view →
KIRC	All	II,III,IV	+0.376	.001	9	view →
LUSC	All	III,IV	+1.538	<.001	8	view →
LUAD	Female	II,III,IV	+0.781	<.001	7	view →
KIRP	Male	II,III,IV	+1.053	.001	6	view →
BLCA	Male	III,IV	+0.985	.003	6	view →
BRCA	All	III,IV	+0.918	<.001	6	view →
UCEC	All	All	+0.730	.002	6	view →
KICH	Female	All	−1.078	<.001	4	view →
STAD	All	All	+0.742	.006	4	view →
CHOL	All	All	+1.194	<.001	2	view →
PRAD	All	All	+0.455	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TXN–LIHC

Open the LIHC breakdown →