TXN

Across TCGA pan-cancer cohorts, TXN RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TXN data layer compared with 3 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TXN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TXN expression acts as an unfavorable survival marker, although some lineages such as UCEC and THYM show a favorable association.

LUAD, ACC, and LIHC are the cancer types where TXN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.716	0.840	<.001	120	view →
ACC	DFS	Median	All	0.256	0.641	<.001	102	view →
LIHC	DFS	Quartile	All	0.450	0.652	<.001	92	view →
HNSC	DFS	Tertile	All	0.512	0.654	.002	71	view →
UCS	OS	Median	IV	0.302	0.817	.002	56	view →
UCEC	OS	Tertile	All	0.830	0.552	.001	52	view →
LGG	DFS	Median	All	0.655	0.821	<.001	49	view →
MESO	OS	Tertile	All	0.307	0.517	.004	36	view →
SKCM	OS	Tertile	III,IV	0.179	0.546	<.001	34	view →
KIRP	DFS	Tertile	All	0.832	0.958	<.001	33	view →
KICH	DFS	Quartile	II,III,IV	0.447	0.925	.008	27	view →
PAAD	DFS	Quartile	All	0.191	0.446	.005	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TXN–LUAD (DFS)

Open the LUAD breakdown →