TXK

Across TCGA patient cohorts, TXK mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXK-associated genes across cancer lineages are Smac, E-Cadherin, and ASNS. Each is linked with TXK in more than 1 cancer types. Because this analysis shows association rather than direction, both TXK-to-partner and partner-to-TXK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smac grouped by TXK-low versus TXK-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXK→partner) and Y-score (partner→TXK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smac →	+0.345	+3.012	.007	.018	3	2
SKCM	E-Cadherin →	+0.905	+2.459	.031	.020	3	2
UCEC	ASNS →	+0.523	+2.321	<.001	.033	3	2
SKCM	N-Ras →	+0.157	+3.584	.016	.002	3	1
SKCM	4E-BP1_pT70 →	+0.204	+2.824	.018	.034	3	1
UCEC	FoxM1 →	+0.235	+1.884	.028	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Smac by TXK expression — SKCM

Explore this box plot interactively →