TXK

Across TCGA pan-cancer cohorts, TXK RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TXK data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TXK RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TXK expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LGG are the cancer types where TXK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.456	0.265	<.001	96	view →
SKCM	OS	Median	All	0.387	0.287	<.001	54	view →
LGG	OS	Median	All	0.740	0.867	<.001	38	view →
KIRC	OS	Median	II,III,IV	0.830	0.743	.024	37	view →
READ	OS	Median	III,IV	0.724	0.264	<.001	37	view →
OV	DFS	Median	III,IV	0.579	0.487	.004	36	view →
ESCA	DFS	Quartile	III,IV	0.665	0.251	<.001	27	view →
BRCA	OS	Tertile	III,IV	0.732	0.479	.021	23	view →
GBM	DFS	Median	All	0.202	0.307	.013	22	view →
KIRP	DFS	Median	All	0.808	0.893	.022	14	view →
LUSC	DFS	Quartile	All	0.696	0.908	.009	12	view →
LIHC	DFS	Median	III,IV	0.574	0.239	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TXK–HNSC (DFS)

Open the HNSC breakdown →