TXK

Across TCGA cell cohorts, TXK mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TXK-associated genes across cancer lineages are PRAMEF10, PRAMEF17, and ZP2. Each is linked with TXK in more than 1 cancer types. Because this analysis shows association rather than direction, both TXK-to-partner and partner-to-TXK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF10 grouped by TXK-low versus TXK-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXK→partner) and Y-score (partner→TXK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	ZP2 →	+0.032	+3.760	<.001	.008	3	1
LUNG_NSCLC_LUAD	PRLHR →	+0.040	+3.947	.006	.004	3	1
LUNG_NSCLC_LUAD	TSPAN16 →	+0.055	+4.157	<.001	.003	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PRAMEF10 by TXK expression — LUNG_SCLC

Explore this box plot interactively →