TWF1

Across TCGA patient cohorts, TWF1 mutation is significantly associated with the RNA expression of many other genes, with 1,964 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TWF1-associated genes across cancer lineages are SNRPGP7, HMGB1P42, and RN7SKP181. Each is linked with TWF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TWF1-to-partner and partner-to-TWF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP7 grouped by TWF1-low versus TWF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TWF1→partner) and Y-score (partner→TWF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNRPGP7 →	+0.447	+4.602	<.001	.008	3	2
COAD	HMGB1P42 →	+0.079	+4.790	<.001	.006	3	2
UCEC	RN7SKP181 →	+0.064	+1.911	.005	.006	3	2
LUAD	RNA5SP157 →	+0.851	+7.930	<.001	.008	3	2
BRCA	RNA5SP137 →	+0.270	+5.045	.001	.009	3	1
PRAD	MIR1202 →	+0.373	+7.939	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,964 associations by consensus.

SNRPGP7 by TWF1 expression — COAD

Explore this box plot interactively →