TWF1

Across TCGA pan-cancer cohorts, TWF1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TWF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TWF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TWF1 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

KIRP, LIHC, and LUAD are the cancer types where TWF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TWF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.805	<.001	11	view →
LIHC	Male	All	+0.829	<.001	9	view →
LUAD	Male	II,III,IV	+1.200	<.001	8	view →
HNSC	All	All	+0.553	.001	8	view →
LUSC	Male	II,III,IV	+1.198	<.001	7	view →
BRCA	All	II,III,IV	+0.603	<.001	6	view →
CHOL	Male	All	+1.786	<.001	5	view →
BLCA	All	IV	+0.595	.008	4	view →
KICH	All	All	+0.600	.005	3	view →
STAD	All	II,III,IV	+0.629	.020	2	view →
PRAD	All	All	−0.218	.032	2	view →
ESCA	All	All	+0.881	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TWF1–KIRP

Open the KIRP breakdown →