TVP23A

Across TCGA patient cohorts, TVP23A mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TVP23A-associated genes across cancer lineages are Notch1, 4E-BP1, and Cyclin-B1. Each is linked with TVP23A in more than 1 cancer types. Because this analysis shows association rather than direction, both TVP23A-to-partner and partner-to-TVP23A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TVP23A-low versus TVP23A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TVP23A→partner) and Y-score (partner→TVP23A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.177	+1.887	.001	.029	3	2
UCEC	4E-BP1 →	+0.413	+3.614	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.652	+3.087	.003	<.001	3	2
UCEC	14-3-3_beta →	-0.080	-2.973	.049	.035	3	1
UCEC	EGFR_pY1068 →	-0.242	-2.415	.016	.003	3	1
UCEC	eIF4E →	+0.251	+3.584	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Notch1 by TVP23A expression — UCEC

Explore this box plot interactively →