TVP23A

Across TCGA pan-cancer cohorts, TVP23A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TVP23A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TVP23A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TVP23A is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

KIRC, LUSC, and THCA are the cancer types where TVP23A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TVP23A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.457	<.001	9	view →
LUSC	Female	II,III,IV	−0.622	<.001	8	view →
THCA	Female	All	−0.351	<.001	8	view →
KICH	All	All	−0.241	<.001	7	view →
UCEC	All	II,III,IV	−1.225	<.001	6	view →
BRCA	All	III,IV	−0.371	<.001	6	view →
BLCA	All	All	−0.238	.025	4	view →
COAD	All	All	−0.156	.002	4	view →
LIHC	All	II,III,IV	+0.150	.007	4	view →
LUAD	All	II,III,IV	−0.258	.020	3	view →
CHOL	All	All	+0.510	<.001	2	view →
PRAD	All	All	−0.491	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TVP23A–KIRC

Open the KIRC breakdown →