TVP23A

Across TCGA pan-cancer cohorts, TVP23A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TVP23A data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TVP23A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TVP23A expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BLCA are the cancer types where TVP23A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.753	0.640	<.001	132	view →
SKCM	OS	Median	II,III,IV	0.451	0.217	<.001	102	view →
BLCA	OS	Quartile	II,III,IV	0.795	0.602	.002	93	view →
BRCA	OS	Quartile	All	0.730	0.537	<.001	37	view →
DLBC	DFS	Tertile	All	1.000	0.631	.004	37	view →
READ	OS	Median	II,III,IV	0.929	0.312	<.001	32	view →
UVM	DFS	Quartile	All	0.311	0.806	.002	24	view →
CESC	OS	Median	All	0.668	0.497	.004	20	view →
THYM	OS	Tertile	All	0.783	1.000	.014	19	view →
GBM	OS	Tertile	All	0.295	0.566	<.001	18	view →
LGG	OS	Quartile	All	0.702	0.835	.006	14	view →
UCEC	DFS	Tertile	III,IV	0.730	0.503	.012	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TVP23A–HNSC (DFS)

Open the HNSC breakdown →