TUNAR

Across TCGA pan-cancer cohorts, TUNAR RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TUNAR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TUNAR RNA is repressed in tumor relative to normal tissue. In most cancer types TUNAR is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where TUNAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUNAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−0.788	<.001	12	view →
KICH	Male	All	−1.407	<.001	7	view →
UCEC	All	All	−1.989	<.001	6	view →
KIRP	Male	All	+1.218	.009	6	view →
THCA	Female	All	+0.446	.008	5	view →
BRCA	Female	II,III,IV	−0.312	.001	4	view →
STAD	All	IV	−0.233	.027	2	view →
READ	Female	All	−0.114	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TUNAR–KIRC

Open the KIRC breakdown →