TUBG2

Across TCGA patient cohorts, TUBG2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBG2-associated genes across cancer lineages are PCNA, eIF4E, and Ku80. Each is linked with TUBG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBG2-to-partner and partner-to-TUBG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TUBG2-low versus TUBG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBG2→partner) and Y-score (partner→TUBG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.299	+2.222	.001	.011	3	2
UCEC	eIF4E →	+0.241	+2.222	.007	.011	3	1
UCEC	Ku80 →	+0.251	+1.884	.012	.030	3	1
UCEC	MEK1 →	+0.343	+2.000	.027	.030	3	1
UCEC	p62 Lck ligand →	+0.403	+2.469	.003	.010	3	1
UCEC	PDK1_pS241 →	+0.221	+2.584	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PCNA by TUBG2 expression — UCEC

Explore this box plot interactively →