Q-omics provides the consensus-scored TUBB8B profile across patient tissues and cancer cell-line models. TUBB8B expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, TUBB8B is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, TUBB8B RNA expression shows 14,285 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight ACC, KIRC, and TGCT as cancer lineages where TUBB8B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TUBB8B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TUBB8B survival associations across molecular data types. TUBB8B RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TUBB8B RNA expression–survival associations across cancer types. High TUBB8B expression shows unfavorable associations in ACC, UCEC, UVM, CHOL and LIHC, but favorable associations in UCS. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for TUBB8B RNA expression.
This table summarizes TUBB8B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 1. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for TUBB8B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TUBB8B shows lower tumor expression in KIRC and KICH and higher tumor expression in STAD, LUSC, LIHC and BLCA. The KIRC box plot shows higher TUBB8B RNA expression in normal versus tumor tissue (log2 FC = −0.192, t-test p < 0.001).
This table shows molecular features associated with TUBB8B in patient tissues and cancer cell lines. In patient samples, TUBB8B shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, TUBB8B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in KIDNEY.
