TUBA3E

Across TCGA patient cohorts, TUBA3E mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBA3E-associated genes across cancer lineages are PCNA, Annexin-1, and 14-3-3_beta. Each is linked with TUBA3E in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBA3E-to-partner and partner-to-TUBA3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TUBA3E-low versus TUBA3E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBA3E→partner) and Y-score (partner→TUBA3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.154	+2.321	.047	.033	3	2
UCEC	Annexin-1 →	+0.759	+3.999	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.078	-3.558	.030	.002	3	1
UCEC	EGFR_pY1068 →	-0.237	-3.700	.008	.001	3	1
UCEC	A-Raf_pS299 →	-0.084	-2.321	.049	.005	3	1
UCEC	ERK2 →	+0.178	+1.925	.010	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PCNA by TUBA3E expression — UCEC

Explore this box plot interactively →