TUBA3E

Across TCGA cell cohorts, TUBA3E mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TUBA3E-associated genes across cancer lineages are OR1L1, CCL8, and KRT32. Each is linked with TUBA3E in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBA3E-to-partner and partner-to-TUBA3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L1 grouped by TUBA3E-low versus TUBA3E-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBA3E→partner) and Y-score (partner→TUBA3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1L1 →	+0.052	+5.029	<.001	.006	3	1
BLOOD_Leukemia	CCL8 →	+0.018	+3.705	.004	.007	3	1
BLOOD_Leukemia	KRT32 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	AADACL2 →	+0.017	+4.507	<.001	.001	3	1
BLOOD_Leukemia	SPINK8 →	+0.284	+3.944	.004	.006	3	1
LARGE_INTESTINE	JAKMIP1 →	+0.221	+2.562	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR1L1 by TUBA3E expression — LUNG_SCLC

Explore this box plot interactively →