TUB

Across TCGA patient cohorts, TUB mutation is significantly associated with the RNA expression of many other genes, with 3,680 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUB-associated genes across cancer lineages are TLE6, RNU4-63P, and MTA2. Each is linked with TUB in more than 3 cancer types. Because this analysis shows association rather than direction, both TUB-to-partner and partner-to-TUB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLE6 grouped by TUB-low versus TUB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUB→partner) and Y-score (partner→TUB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TLE6 →	+0.758	+3.348	<.001	.005	3	3
COAD	RNU4-63P →	+0.288	+3.973	<.001	.008	3	3
UCEC	MTA2 →	+0.338	+1.700	<.001	.001	3	3
UCEC	BAG3 →	+0.425	+1.347	.002	.007	3	3
UCEC	MNAT1 →	+0.370	+1.601	.003	.005	2	4
UCEC	THRAP3 →	+0.324	+1.815	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,680 associations by consensus.

TLE6 by TUB expression — COAD

Explore this box plot interactively →