TUB

Across TCGA pan-cancer cohorts, TUB RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TUB data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TUB RNA is associated with better overall survival. In most high-consensus cancer types, elevated TUB expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

LGG, BLCA, and COAD are the cancer types where TUB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.536	0.350	<.001	46	view →
BLCA	DFS	Tertile	II,III,IV	0.244	0.410	.007	45	view →
COAD	DFS	Median	All	0.602	0.766	.001	39	view →
PAAD	OS	Median	All	0.483	0.284	.001	39	view →
KIRC	OS	Median	All	0.708	0.561	<.001	32	view →
STAD	OS	Quartile	III,IV	0.235	0.606	.013	30	view →
ACC	OS	Median	IV	0.799	0.287	.006	25	view →
HNSC	OS	Tertile	All	0.300	0.570	.004	20	view →
KIRP	DFS	Median	All	0.945	0.626	.004	19	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	18	view →
LUSC	DFS	Tertile	III,IV	0.512	0.751	.014	15	view →
LIHC	OS	Quartile	II,III,IV	0.393	0.803	.005	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TUB–LGG (OS)

Open the LGG breakdown →