TUB

Across TCGA pan-cancer cohorts, TUB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TUB’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TUB RNA is repressed in tumor relative to normal tissue. In most cancer types TUB is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and COAD are the cancer types where TUB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.975	<.001	10	view →
KIRP	All	III,IV	−1.711	<.001	9	view →
COAD	Female	II,III,IV	−0.985	<.001	9	view →
BLCA	Male	IV	−2.967	<.001	8	view →
LUAD	All	III,IV	−0.892	<.001	8	view →
KIRC	Male	II,III,IV	−0.972	<.001	7	view →
LIHC	All	II,III,IV	+0.680	<.001	7	view →
UCEC	All	All	−3.283	<.001	6	view →
BRCA	All	III,IV	−1.123	<.001	6	view →
STAD	All	All	−0.984	<.001	6	view →
CHOL	All	All	+1.547	.004	2	view →
READ	All	All	−1.410	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TUB–THCA

Open the THCA breakdown →