TUB

Across TCGA patient cohorts, TUB mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUB-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and CDK1. Each is linked with TUB in more than 2 cancer types. Because this analysis shows association rather than direction, both TUB-to-partner and partner-to-TUB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TUB-low versus TUB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUB→partner) and Y-score (partner→TUB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.268	+2.415	.001	.002	3	3
UCEC	Cyclin-B1 →	+0.628	+2.999	<.001	<.001	3	3
COAD	CDK1 →	+0.287	+2.820	<.001	.035	3	3
UCEC	eIF4E →	+0.138	+2.598	.038	.005	3	2
UCEC	Akt_pT308 →	+0.465	+1.137	.019	.041	3	2
COAD	Rad50 →	-0.314	-2.974	.005	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

4E-BP1 by TUB expression — UCEC

Explore this box plot interactively →