TUB

Across TCGA cell cohorts, TUB mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TUB-associated genes across cancer lineages are OR2H1, ATP5F1A, and CCER1. Each is linked with TUB in more than 1 cancer types. Because this analysis shows association rather than direction, both TUB-to-partner and partner-to-TUB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2H1 grouped by TUB-low versus TUB-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUB→partner) and Y-score (partner→TUB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR2H1 →	+0.042	+5.321	<.001	.005	3	1
LARGE_INTESTINE	ATP5F1A →	+0.891	+3.082	.001	.007	3	1
LARGE_INTESTINE	CCER1 →	+0.007	+2.977	<.001	.006	3	1
LARGE_INTESTINE	TECRL →	+0.009	+2.977	.001	.006	3	1
LARGE_INTESTINE	IQCF6 →	+0.148	+2.560	.002	.008	3	1
LARGE_INTESTINE	H2BC3 →	+0.142	+2.518	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR2H1 by TUB expression — CNS

Explore this box plot interactively →