TTLL8

Across TCGA patient cohorts, TTLL8 mutation is significantly associated with the RNA expression of many other genes, with 1,823 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL8-associated genes across cancer lineages are CICP6, RNU6-260P, and RAET1K. Each is linked with TTLL8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTLL8-to-partner and partner-to-TTLL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CICP6 grouped by TTLL8-low versus TTLL8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL8→partner) and Y-score (partner→TTLL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CICP6 →	+0.029	+4.067	<.001	.001	3	3
COAD	RNU6-260P →	+0.407	+3.212	.005	.007	3	2
COAD	RAET1K →	+0.356	+3.210	.008	.009	3	2
COAD	LINC02663 →	+0.247	+3.051	<.001	.003	3	2
UCEC	SEC13 →	+0.419	+2.584	<.001	.001	3	2
UCEC	AKIP1 →	+0.486	+2.931	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,823 associations by consensus.

CICP6 by TTLL8 expression — LUSC

Explore this box plot interactively →