TTLL8

Across TCGA pan-cancer cohorts, TTLL8 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TTLL8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTLL8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTLL8 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where TTLL8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTLL8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.040	<.001	12	view →
LUAD	All	III,IV	+0.040	<.001	7	view →
LUSC	Male	II,III,IV	+0.041	.001	4	view →
STAD	Male	IV	−0.065	.005	2	view →
COAD	All	All	+0.026	.032	2	view →
PRAD	All	All	+0.016	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TTLL8–HNSC

Open the HNSC breakdown →