TTLL8

Across TCGA pan-cancer cohorts, TTLL8 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated TTLL8 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TTLL8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTLL8 expression acts as an unfavorable survival marker, although some lineages such as UCS and DLBC show a favorable association.

KIRC, UVM, and ACC are the cancer types where TTLL8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	IV	0.199	0.421	.001	91	view →
UVM	DFS	Tertile	All	0.379	0.902	<.001	73	view →
ACC	OS	Tertile	II,III,IV	0.218	0.768	<.001	73	view →
THCA	OS	Quartile	III,IV	0.853	0.970	.003	50	view →
UCS	DFS	Median	II,III,IV	0.711	0.245	<.001	48	view →
DLBC	OS	Median	All	1.000	0.527	.004	35	view →
LIHC	DFS	Tertile	II,III,IV	0.096	0.284	.011	21	view →
KICH	DFS	Tertile	IV	0.317	0.923	.038	18	view →
LUAD	DFS	Tertile	IV	0.102	0.765	.017	12	view →
LGG	DFS	Median	All	0.364	0.507	.028	11	view →
MESO	OS	Median	All	0.727	0.343	.032	9	view →
READ	DFS	Tertile	IV	0.095	0.697	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

TTLL8–KIRC (DFS)

Open the KIRC breakdown →