TTLL8

Across TCGA patient cohorts, TTLL8 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL8-associated genes across cancer lineages are mTOR_pS2448, p62 Lck ligand, and PCNA. Each is linked with TTLL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL8-to-partner and partner-to-TTLL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TTLL8-low versus TTLL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL8→partner) and Y-score (partner→TTLL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.155	-2.302	.014	.034	3	2
UCEC	p62 Lck ligand →	+0.369	+2.906	.007	.001	3	2
UCEC	PCNA →	+0.198	+1.700	.030	.044	3	2
UCEC	Stathmin →	+0.157	+2.222	.006	.011	3	2
UCEC	VEGFR2 →	+0.259	+2.459	.040	.018	3	2
SKCM	YAP_pS127 →	-0.373	-3.169	.045	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

mTOR_pS2448 by TTLL8 expression — UCEC

Explore this box plot interactively →