TTLL8

Across TCGA cell cohorts, TTLL8 mutation is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTLL8-associated genes across cancer lineages are OR2M4, OR13C2, and GCAT. Each is linked with TTLL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL8-to-partner and partner-to-TTLL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M4 grouped by TTLL8-low versus TTLL8-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL8→partner) and Y-score (partner→TTLL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2M4 →	+0.076	+4.700	<.001	.002	3	1
OVARY	OR13C2 →	+0.046	+4.228	.009	.006	3	1
LARGE_INTESTINE	GCAT →	+1.232	+3.364	.002	.002	3	1
LARGE_INTESTINE	AVP →	+0.036	+2.824	<.001	.001	3	1
LARGE_INTESTINE	KCNQ4 →	+0.963	+3.364	<.001	.002	3	1
LARGE_INTESTINE	KDSR →	+0.708	+3.364	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

OR2M4 by TTLL8 expression — OVARY

Explore this box plot interactively →