TTL

Across TCGA patient cohorts, TTL mutation is significantly associated with the RNA expression of many other genes, with 2,994 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTL-associated genes across cancer lineages are RN7SL248P, MIR3973, and RN7SL817P. Each is linked with TTL in more than 1 cancer types. Because this analysis shows association rather than direction, both TTL-to-partner and partner-to-TTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by TTL-low versus TTL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTL→partner) and Y-score (partner→TTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.083	+3.400	<.001	.003	3	2
UCEC	MIR3973 →	+0.284	+3.736	<.001	.009	3	2
BLCA	RN7SL817P →	+0.252	+5.106	<.001	.008	3	2
UCEC	LIN7C →	+0.808	+3.021	<.001	<.001	3	1
UCEC	SCGB1A1 →	-1.736	-3.576	.004	.002	3	1
UCEC	ZNF215 →	+0.652	+2.831	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,994 associations by consensus.

RN7SL248P by TTL expression — UCEC

Explore this box plot interactively →