TTL

Across TCGA pan-cancer cohorts, TTL RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TTL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTL is over-expressed in tumor, although a few such as KIRC and PAAD show the opposite, repressed pattern.

HNSC, COAD, and KIRP are the cancer types where TTL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.801	<.001	12	view →
COAD	Female	II,III,IV	+0.876	<.001	11	view →
KIRP	All	III,IV	+0.805	<.001	11	view →
LIHC	Male	II,III,IV	+1.297	<.001	9	view →
THCA	Male	All	+0.493	<.001	9	view →
READ	Male	All	+0.990	.007	6	view →
LUSC	Female	All	+0.682	<.001	6	view →
KIRC	Male	II,III,IV	−0.369	<.001	6	view →
CHOL	Male	All	+1.859	<.001	5	view →
STAD	All	II,III,IV	+0.844	<.001	5	view →
UCEC	All	II,III,IV	+0.763	.019	4	view →
BRCA	All	II,III,IV	+0.199	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TTL–HNSC

Open the HNSC breakdown →