TTK

Across TCGA cell cohorts, TTK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,364 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTK-associated GO terms across cancer lineages are Meiotic chromosome segregation, Spindle elongation, and Mitotic spindle assembly. Each is linked with TTK in more than 19 cancer types. Because this analysis shows association rather than direction, both TTK-to-partner and partner-to-TTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic chromosome segregation grouped by TTK-low versus TTK-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTK→partner) and Y-score (partner→TTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Meiotic chromosome segregation →	+0.189	+1.369	<.001	.001	3	20
KIDNEY	Spindle elongation →	+0.246	+1.286	<.001	<.001	3	20
SKIN	Mitotic spindle assembly →	+0.116	+1.192	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Regulation of G2/M transition of mitotic cell cycle →	+0.119	+1.481	<.001	<.001	3	20
OESOPHAGUS	Regulation of mitotic sister chromatid separation →	+0.255	+1.468	<.001	<.001	3	20
OESOPHAGUS	Positive regulation of chromosome condensation →	+0.260	+1.467	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,364 associations by consensus.

Meiotic chromosome segregation by TTK expression — OESOPHAGUS

Explore this box plot interactively →